The Relationship Between Glycosylated Hemoglobin and Myocardial Perfusion Imaging Full Text
Clinical Cardiology, 07/11/2012
Fillipon NML et al. – The importance of strict glycemic control to reduce cardiovascular complications in diabetic patients is well known. The study shows a significantly higher risk of abnormal myocardial perfusion imaging (MPI) and coronary artery disease (CAD) in diabetic patients with suboptimal and poor long–term glycemic control, further emphasizing the need for aggressive risk factor modification to minimize vascular complications from DM.Methods
- This was a retrospective evaluation of 1037 consecutive patients referred for MPI.
- All patients completed a 1-day MPI protocol.
- The electronic medical records were accessed for demographics and relevant medical history.
- Diabetic patients had a higher risk of abnormal MPI (including ischemia, infarction, and mixed ischemia/infarction) compared to nondiabetic patients (relative risk [RR] = 1.77).
- The populations with suboptimal (HgbA1C ≥7%) and poor (HgbA1C ≥8%) glycemic control had significantly higher risk of abnormal MPI (RR = 1.78 and 2.17, respectively) compared to nondiabetic patients.
- Coronary angiography supported the MPI results; 66% of diabetic patients had coronary artery disease (CAD), which was higher than the 53% of patients without diabetes found to have CAD.