Torsades de pointes following acute myocardial infarction: Evidence for a deadly link with a common genetic variant
Heart Rhythm, 07/11/2012
Crotti L et al. – This data suggest that the common K897T polymorphism is associated with an increased risk of TdP developing in the subacute phase of MI. These findings support the concept that the electrical remodeling associated with this healing phase of MI may unmask a genetic substrate predisposing to a time–limited development of life–threatening arrhythmias. They also provide the first line of evidence in support of the hypothesis that a common polymorphism, previously described as a modifier of the severity of LQTS, may increase the risk of life–threatening arrhythmias in a much more prevalent cardiac disease such as myocardial infarction.