Relationship between central arterial pulse pressure and abnormal circadian rhythm of blood pressure in patients with essential hypertension
American Journal of Hypertension, 07/06/2012
Xue–sen L et al. – Central arterial pulse pressure is correlated with nocturnal blood pressure (BP) descending rate and to some extent with reverse–dipper hypertension.Methods
- 190 cases of essential hypertensive patients were enrolled.
- All the subjects were of Han nationality including 96 males and 94 females, with the average age of 59.7±12.8 years.
- Circadian BP rhythm was detected and nocturnal BP descending rate was calculated.
- Nocturnal BP fall was classified as follows: reverse–dipper (n=59), if the rate was <0%; non–dipper (n=73), if it was ≥0% but <10%; and dipper (n=58), if it was <20%.
- The differences and relationships between CAPP and reflected wave augmentation index (AI), brachial–ankle pulse wave velocity (baPWV) were analyzed.
- Nocturnal SBP, DBP and MAP in reverse–dipper subjects were statistically higher than those in non–dipper and dippers cases (P<0.05).
- Daytime DBP and MAP in reverse–dippers and non–dippers cohort were significantly lower than dipper individuals (P<0.05).
- The risk of non–dipper hypertension increased to 1.13 times for every increase of 10mm Hg in CAPP (OR 1.13, 95% CI 1.04–1.27, P<0.05).
- The risk of hypertension in reverse–dipper increased to 1.26 times (OR 1.26, 95% CI 1.00–1.39, P<0.05) for every increase of 10 unit in AI corrected for a heart rate of 75 beats per minute (AIx75). baPWV was correlated strongly with reverse–dipper hypertension (P<0.05).