Time course of histomorphological changes in adipose tissue upon acute lipoatrophy
Nutrition, Metabolism & Cardiovascular Diseases, 06/22/2012
Murano I et al. – These data demonstrate that CLS formation results as a direct consequence of adipocyte death, and that infiltrating macrophages actively uptake remnant lipids of dead adipocytes. Upon induction of adipocyte apoptosis, inflammatory cells infiltrate adipose tissue initially consisting of neutrophils followed by macrophages that are involved in CLS formation.