Probenecid: Novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation
Journal of Molecular and Cellular Cardiology, 06/21/2012
Koch SE et al. – Analysis of the expression of Ca2+ handling and β–adrenergic signaling pathway proteins showed that the contractility was not increased through activation of the β–ADR. Authors propose that the response to probenecid is due to activation of TRPV2 channels secondary to SR release of Ca2+.