The role of irbesartan in the treatment of patients with hypertension: a comprehensive and practical review
High Blood Pressure & Cardiovascular Prevention,  Clinical Article

Borghi C et al. – Irbesartan is an orally active angiotensin II type 1 receptor antagonist (angiotensin receptor blocker [ARB]) whose pharmacological profile differs significantly from those of many other compounds of the same class.

  • In particular, according to its pharmacokinetic and pharmacodynamic profile, irbesartan has a high bioavailability, a long duration of action and a small potential for pharmacological interactions due to the nature of the enzymatic pathway involved in its metabolic process.
  • Morbidity data with irbesartan have been mainly accumulated in patients with renal impairment where the drug has demonstrated the most remarkable evidence of efficacy among the ARBs class, regardless of the stage of the renal disease (from early to late) and the length of the observational period.
  • The efficacy of irbesartan has also been demonstrated in patients with left ventricular hypertrophy and congestive heart failure.
  • The drug is indicated for the treatment of hypertension and renal impairment in patients with type 2 diabetes mellitus (T2D) and hypertension, and its tolerability and safety profile have been extensively investigated and reported to be similar to placebo.
  • From the pharmacoeconomic point of view, treating patients with T2D, hypertension and overt nephropathy using irbesartan was both a cost– and life–saving procedure compared with the use of amlodipine and standard antihypertensive treatment in an Italian setting.
  • The role of irbesartan in the management of hypertension with or without T2D and renal impairment is clearly recognized by national and international guidelines and largely acknowledged by the medical community according to the efficacy of the drug in the prevention of cardiovascular risk in addition to and beyond kidney prevention.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Cardiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Cardiology Articles

1 Rivaroxaban vs. vitamin K antagonists for cardioversion in atrial fibrillation European Heart Journal, September 16, 2014    Clinical Article

2 Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials Hypertension, September 29, 2014    Evidence Based Medicine    Review Article

3 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

4 A systematic review of statin-induced muscle problems in clinical trials American Heart Journal, October 7, 2014    Review Article

5 Thromboembolic risk in 16 274 atrial fibrillation patients undergoing direct current cardioversion with and without oral anticoagulant therapy EP Europace, September 19, 2014    Clinical Article

6 Effect of statins in preventing contrast-induced nephropathy: an updated meta-analysis Coronary Artery Disease, October 2, 2014    Clinical Article

7 Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease The American Journal of Cardiology, September 5, 2014    Clinical Article

8 Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: Final baseline characteristics of the IMPROVE-IT study population American Heart Journal, October 6, 2014    Clinical Article

9 Effect of Nicorandil in patients with heart failure: A systematic review and meta-analysis Cardiovascular Therapeutics, October 17, 2014    Evidence Based Medicine    Review Article    Clinical Article

10 New oral anticoagulants for the treatment of venous thromboembolism: understanding differences and similarities Drugs, October 10, 2014    Review Article

11 The effect of indapamide versus hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: Results of a randomized trial American Heart Journal, October 1, 2014    Clinical Article

12 Effect of different dose aspirin on coronary artery lesions in the acute phase of Kawasaki disease JACC - Journal of the American College of Cardiology, October 21, 2014    Clinical Article

13 Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid Journal of Thrombosis and Haemostasis, September 25, 2014    Clinical Article

14 Efficacy of dronedarone versus propafenone in the maintenance of sinus rhythm in patients with atrial fibrillation after electrical cardioversion Clinical Therapeutics, August 19, 2014    Clinical Article

15 Efficacy and safety of apixaban compared with warfarin for stroke prevention in patients with atrial fibrillation from East Asia: A subanalysis of the apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial American Heart Journal, October 13, 2014    Clinical Article

16 Tea consumption is inversely related to 5-year blood pressure change among adults in Jiangsu, China: A cross-sectional study Full Text Nutrition Journal, October 24, 2014    Free full text    Clinical Article

17 Endovascular versus medical therapy for atherosclerotic renovascular disease Current Atherosclerosis Reports, October 23, 2014    Clinical Article

18 Starting primary prevention earlier with statins The American Journal of Cardiology, October 15, 2014    Clinical Article

19 Ischemic postconditioning versus remote ischemic conditioning in patients treated with primary percutaneous coronary intervention: A Bayesian network meta-analysis JACC - Journal of the American College of Cardiology, October 16, 2014    Clinical Article

20 Prasugrel vs. clopidogrel in acute coronary syndrome patients treated with prasugrel Journal of Clinical Pharmacy and Therapeutics, September 24, 2014    Clinical Article

Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heartmore