Ranolazine stabilizes cardiac ryanodine receptors: A novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2
Heart Rhythm, 05/24/2012
Clinical Article
Parikh A et al. – Ran reduces Po of Ran on cardiac ryanodine receptors (RyR2), desensitizes Ca2+–dependent RyR2 activation, and inhibits Cai oscillations, which represents a novel mechanism for its suppression of early afterdepolarization (EADs) and TdP.



