mdlinx mdlinx
Latest (65) Full Text Articles (3243) Focus on Risk Factors Article Summary

Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock
Critical Care,  Clinical Article

Linder A et al. – Plasma heparin–binding protein (HBP) levels were significantly higher in patients with severe sepsis or septic shock compared to patients with non–septic illness in the intensive care unit (ICU). HBP was associated with severity of disease, and an elevated HBP at admission was associated with an increased risk of death. HBP that rises over time may identify patients with a deteriorating prognosis. Thus, repeated HBP measurement in the ICU may help monitor treatment and predict outcome in patients with severe infections.

Methods
  • A prospective study of two patient cohorts treated in the ICU at Karolinska University Hospital Huddinge in Sweden.
  • 179 patients were included, of whom 151 had sepsis (126 with septic shock and 25 patients with severe sepsis) and 28 a non–septic critical condition.
  • Blood samples were collected at five time points during six days after admission.

Results
  • HBP levels were significantly higher in the sepsis group as compared to the control group.
  • At admission to the ICU, a plasma HBP concentration of [greater than or equal to]15ng/mL and/or a HBP(ng/mL) / White blood cell count (109/L) ratio of >2 was found in 87.2% and 50.0% of critically ill patients with sepsis and non–septic illness, respectively.
  • A lactate level of >2.5mmol/L was detected in 64.9% and 56.0% of the same patient groups.
  • Both in the sepsis group (n=151) and in the whole group (n=179), plasma HBP concentrations at admission and in the last measured sample within the 144hour study period were significantly higher among 28–day non–survivors as compared to survivors, and in the sepsis group, an elevated HBP–level at baseline was associated with an increased case–fatality rate at 28days.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Cardiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Cardiology Articles

Last month's top read Top Articles of 2013

1 Vitamin D deficiency and coronary artery disease: A review of the evidence American Heart Journal, March 5, 2014    Review Article

2 Medical therapy versus implantable cardioverter -defibrillator in preventing sudden cardiac death in patients with left ventricular systolic dysfunction and heart failure: A meta-analysis of >35,000 patients International Journal of Cardiology, March 17, 2014    Clinical Article

3 Atenolol versus non-atenolol beta-blockers for the treatment of hypertension: a meta analysis Canadian Journal of Cardiology, February 10, 2014    Evidence Based Medicine    Review Article    Clinical Article

4 Beta blockers in hypertension: studies and meta-analyses over the years Canadian Journal of Cardiology, March 21, 2014    Evidence Based Medicine    Review Article    Clinical Article

5 Serum levels of fetuin-A, osteoprotegerin and osteopontin in patients with coronary artery disease: Effects of Statin (HMGCoA-Reductase Inhibitor) Therapy Clinical Drug Investigation, March 3, 2014    Clinical Article

6 Efficacy and safety of high dose versus low dose furosemide with or without dopamine infusion: The Dopamine in Acute Decompensated Heart Failure II (DAD-HF II) Trial International Journal of Cardiology, February 18, 2014    Clinical Article

7 Comparative coronary risks of apixaban, rivaroxaban and dabigatran: A meta-analysis and adjusted indirect comparison British Journal of Clinical Pharmacology, March 13, 2014    Evidence Based Medicine

8 Rivaroxaban and dabigatran in patients undergoing catheter ablation of atrial fibrillation EP Europace, March 4, 2014    Clinical Article

9 Aspirin use in heart failure Circulation: Heart Failure, March 20, 2014    Clinical Article

10 Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: A randomized, placebo-controlled trial Full Text Nutrition Journal, November 15, 2013    Free full text    Clinical Article

11 Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting The American Journal of Cardiology, January 30, 2014    Evidence Based Medicine    Review Article    Clinical Article

12 What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice European Journal of Preventive Cardiology, March 18, 2014    Evidence Based Medicine    Review Article    Clinical Article

13 An unusual cause of dyspnoea in a young man European Heart Journal, March 3, 2014

14 Update on the efficacy of statin treatment in Acute Coronary Syndromes European Journal of Clinical Investigation, March 14, 2014    Review Article    Clinical Article

15 Application of new cholesterol guidelines to a population-based sample New England Journal of Medicine, March 24, 2014    Evidence Based Medicine    Clinical Guideline    Clinical Article

16 Long-term coffee consumption and risk of cardiovascular disease Circulation, February 11, 2014    Evidence Based Medicine    Review Article    Clinical Article

17 Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: Observations from the ARISTOTLE trial European Heart Journal, February 28, 2014    Clinical Article

18 High diet quality is associated with a lower risk of cardiovascular disease and all-cause mortality in older men The Journal of Nutrition, March 3, 2014    Clinical Article

19 Effect of switch to the highest dose of rosuvastatin versus add-on-statin fenofibrate versus add-on-statin nicotinic acid/laropiprant on oxidative stress markers in patients with mixed dyslipidemia Cardiovascular Therapeutics, March 26, 2014    Clinical Article

20 Dietary patterns, Mediterranean diet, and cardiovascular disease Current Opinion in Lipidology, March 7, 2014    Review Article

Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heartmore

Other Topics in Cardiology

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close