Cholesteryl Ester Transfer Protein and ATP-Binding Cassette Transporter A1 Genotype Alter the Atorvastatin and Simvastatin Efficacy: Time for Genotype-Guided Therapy
Kolovou G et al. – The TaqIB and R219K gene polymorphisms seem to modify the response to lipid–lowering therapy with simvastatin or atorvastatin treatment.Methods
- The authors compared the efficacy of atorvastatin with simvastatin according to cholesteryl ester transfer protein (CETP) and adenosine triphosphate–binding cassette transporter A1 (ABCA1) genes.
- Patients treated with atorvastatin (n = 254) or simvastatin (n = 332) were genotyped for CETP (TaqIB and I405V) and ABCA1 (R219K) genetic variants.
- For genotype B1B2, atorvastatin compared with simvastatin treatment resulted in a greater decrease in total cholesterol (35.4% vs 31.6%, P = .035) and a lower increase in high–density lipoprotein cholesterol (2% vs 8%, P = .05).
- For genotype B2B2, atorvastatin compared with simvastatin treatment resulted in a lower decrease in low–density lipoprotein cholesterol (31.85 vs 42%, P = .029).
- For genotypes RR and KK, atorvastatin compared with simvastatin treatment resulted in a greater decrease of triglycerides (27% vs 17% and 35% vs 15%, respectively; P = .02 for all comparisons).