Current management and future directions for the treatment of patients hospitalized for heart failure with low blood pressure
Heart Failure Reviews,

Gheorghiade M et al. – The objectives of this meeting were to (1) develop a working definition for HF–LBP, (2) describe its clinical characteristics and pathophysiology, (3) review current therapies and their limitations, (4) discuss novel agents in development and (5) create a framework for the design and conduct of future clinical trials.

  • Although patients hospitalized with heart failure have relatively low in–hospital mortality, the post–discharge rehospitalization and mortality rates remain high despite advances in treatment.
  • Most patients admitted for heart failure have normal or high blood pressure, but 15–25 % have low systolic blood pressure with or without signs and/or symptoms of hypoperfusion.
  • All pharmacological agents known to improve the prognosis of patients with heart failure also reduce blood pressure, and this limits their use in patients with heart failure and low blood pressure (HF–LBP).
  • However, patients with HF–LBP have much higher in–hospital and post–discharge mortality.
  • In these patients, a conceptually important therapeutic target is to improve cardiac output in order to alleviate signs of hypoperfusion.
  • Accordingly, the majority of these patients will require an inotrope as cardiac dysfunction is the cause of their low cardiac output.
  • However, the short–term use of currently available inotropes has been associated with further decreases in blood pressure and increases in heart rate, myocardial oxygen consumption and arrhythmias.
  • Agents that improve cardiac contractility without this undesirable effects should be developed.
  • The epidemiology, pathophysiology and therapy of patients with HF–LBP have not been addressed thoroughly.
  • In June 2010, a workshop that included scientists and clinicians was held in Rome, Italy.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Cardiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Cardiology Articles

1 Discontinuation of smokeless tobacco and mortality risk after myocardial infarction Circulation, July 25, 2014    Clinical Article

2 Efficacy of dronedarone versus propafenone in the maintenance of sinus rhythm in patients with atrial fibrillation after electrical cardioversion Clinical Therapeutics, August 19, 2014    Clinical Article

3 Beta-blockers in heart failure with preserved ejection fraction: A meta-analysis Heart Failure Reviews, July 28, 2014    Evidence Based Medicine    Review Article    Clinical Article

4 Egg consumption and cardiovascular disease among diabetic individuals: a systematic review of the literature Full Text Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, July 30, 2014    Free full text    Review Article

5 Beta-blocker therapy and cardiac events among patients with newly diagnosed coronary heart disease JACC - Journal of the American College of Cardiology, July 18, 2014

6 Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease The American Journal of Cardiology, August 28, 2014    Clinical Article

7 A statin a day to keep the doctor away? comparing aspirin and statins for primary prevention of cardiovascular disease Annals of Pharmacotherapy, August 7, 2014    Clinical Article

8 Calcium channel blocker compared with angiotensin receptor blocker for patients with hypertension: a meta-analysis of randomized controlled trials The Journal of Clinical Hypertension, August 13, 2014    Evidence Based Medicine    Review Article    Clinical Article

9 Drug-eluting stents versus coronary artery bypass grafting in diabetic patients with multi-vessel disease: a meta-analysis Heart, Lung, and Circulation, August 6, 2014    Evidence Based Medicine    Review Article

10 Efficacy and safety of pitavastatin versus simvastatin: A meta-analysis of randomized controlled trials Clinical Drug Investigation, August 4, 2014    Evidence Based Medicine    Review Article

11 Minimally invasive direct coronary bypass grafting versus percutaneous coronary intervention for single-vessel disease: A meta-analysis of 2885 patients European Journal of Cardio-Thoracic Surgery, August 14, 2014    Evidence Based Medicine    Review Article    Clinical Article

12 The preventive effect of atorvastatin on atrial fibrillation: a meta-analysis of randomized controlled trials Full Text BMC Cardiovascular Disorders, August 27, 2014    Free full text    Evidence Based Medicine    Review Article    Clinical Article

13 Statin use and mortality among blacks and whites in the Southeastern US Full Text Clinical Epidemiology, August 11, 2014    Free full text    Clinical Article

14 Effects of lipophilic statins for heart failure: a meta-analysis of 13 randomised controlled trials Heart, Lung, and Circulation, August 8, 2014    Evidence Based Medicine    Review Article    Clinical Article

15 Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: Final baseline characteristics of the IMPROVE-IT study population American Heart Journal, July 29, 2014    Clinical Article

16 Ranolazine effectively suppresses atrial fibrillation in the setting of heart failure Circulation: Heart Failure, July 24, 2014    Clinical Article

17 Short and long-term effects of continuous versus intermittent loop diuretics treatment in acute heart failure with renal dysfunction Internal and Emergency Medicine, August 25, 2014    Clinical Article

18 Statins in the elderly: an answered question Current Opinion in Cardiology, June 9, 2014    Evidence Based Medicine    Review Article    Clinical Article

19 Bivalirudin versus heparin in patients planned for percutaneous coronary intervention: a meta-analysis of randomised controlled trials The Lancet, August 20, 2014    Evidence Based Medicine    Clinical Article

20 Combination therapy with aliskiren versus ramipril or losartan added to conventional therapy in patients with type 2 diabetes mellitus, uncontrolled hypertension and microalbuminuria Journal of the Renin-Angiotensin-Aldosterone System, August 1, 2014    Clinical Article

Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heartmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close