Apolipoprotein C-III and hepatic triglyceride-rich lipoprotein production
Current Opinion in Lipidology, 05/31/2012
Yao Z et al. – The current review summarizes recent experimental evidence for an intrahepatic role of human apo C–III in promoting mobilization and utilization of triglyceride during VLDL1 assembly/secretion. Understanding mechanisms by which hepatic apo C–III expression is regulated under insulin resistance and diabetic conditions will lead to better and more rational strategies for the prevention and treatment of diabetic hypertriglyceridemia that is closely related to premature atherosclerosis.