Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms
Circulation Research, 05/11/2012
Haworth RS et al. – PKD–mediated HDAC5 phosphorylation and nuclear export are unlikely to be of major importance in regulating MEF2–driven cardiac remodeling in the presence of sympathetic activity with intact β1–AR signaling, which would not only counteract HDAC5 phosphorylation but also induce HDAC5 nuclear export through a novel phosphorylation–independent, oxidation–mediated mechanism. Inhibition of this mechanism may contribute to the therapeutic efficacy of β1–AR antagonists in heart failure.