Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM-1) as Predictors of Incident CKD Stage 3: The Atherosclerosis Risk in Communities (ARIC) Study
American Journal of Kidney Diseases,  Clinical Article

Bhavsar NA et al. - Higher Neutrophil gelatinase-associated lipocalin (NGAL), but not kidney injury molecule 1 (KIM-1), levels were associated with incident chronic kidney disease (CKD) stage 3. Adjustment for urinary creatinine and albumin concentration attenuated this association. Additional studies are needed to confirm these findings and assess the utility of urinary NGAL as a marker of CKD risk.

Methods
  • Matched case-control study.
  • African American and white participants from the Atherosclerosis Risk in Communities (ARIC) Study who at baseline had an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 and urinary albumin-creatinine ratio ≤30 mg/g.
  • 143 controls were matched for age, sex, and race to 143 cases of incident CKD stage 3 after 8.6 years of follow-up.
  • Quartile of NGAL and KIM-1.
  • Incident CKD stage 3 (eGFR <60 mL/min/1.73 m2 at follow-up and a decrease in eGFR from baseline to follow-up ≥25%).

Results
  • Both NGAL (P = 0.05) and KIM-1 levels (P < 0.001) were correlated positively with baseline urinary albumin-creatinine ratio; neither was associated with baseline eGFR.
  • Participants with NGAL concentrations in the fourth quartile had more than 2-fold higher odds (adjusted OR, 2.11; 95% CI, 0.96-4.64) of incident CKD stage 3 compared with participants in the first quartile after multivariable adjustment (P-trend = 0.03).
  • Adjustment for urinary creatinine and albumin levels resulted in a nonsignificant association (highest quartile adjusted OR, 1.52; 95% CI, 0.64-3.58; P = 0.2).
  • No significant association between KIM-1 level and incident CKD was observed in crude or adjusted models.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Cardiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Cardiology Articles

1 Rivaroxaban vs. vitamin K antagonists for cardioversion in atrial fibrillation European Heart Journal, September 16, 2014    Clinical Article

2 Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials Hypertension, September 29, 2014    Evidence Based Medicine    Review Article

3 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

4 A systematic review of statin-induced muscle problems in clinical trials American Heart Journal, October 7, 2014    Review Article

5 Thromboembolic risk in 16 274 atrial fibrillation patients undergoing direct current cardioversion with and without oral anticoagulant therapy EP Europace, September 19, 2014    Clinical Article

6 Effect of statins in preventing contrast-induced nephropathy: an updated meta-analysis Coronary Artery Disease, October 2, 2014    Clinical Article

7 Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease The American Journal of Cardiology, September 5, 2014    Clinical Article

8 Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: Final baseline characteristics of the IMPROVE-IT study population American Heart Journal, October 6, 2014    Clinical Article

9 Effect of Nicorandil in patients with heart failure: A systematic review and meta-analysis Cardiovascular Therapeutics, October 17, 2014    Evidence Based Medicine    Review Article    Clinical Article

10 New oral anticoagulants for the treatment of venous thromboembolism: understanding differences and similarities Drugs, October 10, 2014    Review Article

11 The effect of indapamide versus hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: Results of a randomized trial American Heart Journal, October 1, 2014    Clinical Article

12 Effect of different dose aspirin on coronary artery lesions in the acute phase of Kawasaki disease JACC - Journal of the American College of Cardiology, October 21, 2014    Clinical Article

13 Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid Journal of Thrombosis and Haemostasis, September 25, 2014    Clinical Article

14 Efficacy of dronedarone versus propafenone in the maintenance of sinus rhythm in patients with atrial fibrillation after electrical cardioversion Clinical Therapeutics, August 19, 2014    Clinical Article

15 Efficacy and safety of apixaban compared with warfarin for stroke prevention in patients with atrial fibrillation from East Asia: A subanalysis of the apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial American Heart Journal, October 13, 2014    Clinical Article

16 Tea consumption is inversely related to 5-year blood pressure change among adults in Jiangsu, China: A cross-sectional study Full Text Nutrition Journal, October 24, 2014    Free full text    Clinical Article

17 Endovascular versus medical therapy for atherosclerotic renovascular disease Current Atherosclerosis Reports, October 23, 2014    Clinical Article

18 Starting primary prevention earlier with statins The American Journal of Cardiology, October 15, 2014    Clinical Article

19 Ischemic postconditioning versus remote ischemic conditioning in patients treated with primary percutaneous coronary intervention: A Bayesian network meta-analysis JACC - Journal of the American College of Cardiology, October 16, 2014    Clinical Article

20 Prasugrel vs. clopidogrel in acute coronary syndrome patients treated with prasugrel Journal of Clinical Pharmacy and Therapeutics, September 24, 2014    Clinical Article

Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heartmore