Differences in hemodynamic responses between intravenous carperitide and nicorandil in patients with acute heart failure syndromes
Heart and Vessels, 05/14/2012
Hattori H et al. – This knowledge may enable physicians in emergency wards to treat and manage patients with acute heart failure syndromes (AHFS) more effectively and safely.Methods
- 28 consecutive patients were assigned to receive 48–h continuous infusion of carperitide (n = 19; 0.0125–0.05 μg/kg/min) or nicorandil (n = 19; 0.05–0.2 mg/kg/h).
- Hemodynamic parameters were estimated at baseline, and 2, 24, and 48 h after drug administration using echocardiography.
- After 48 h of infusion, systolic BP was significantly more decreased in the carperitide group compared with that in the nicorandil group (22.1 ± 20.0 % vs 5.3 ± 10.4 %, P = 0.003).
- While both carperitide and nicorandil significantly improved hemodynamic parameters, improvement of estimated pulmonary capillary wedge pressure was greater in the carperitide group (38.2 ± 14.5 % vs 26.5 ± 18.3 %, P = 0.036), and improvement of estimated cardiac output was superior in the nicorandil group (52.1 ± 33.5 % vs 11.4 ± 36.9 %, P = 0.001).
- Urine output for 48 h was greater in the carperitide group, but not to a statistically significant degree (4203 ± 1542 vs 3627 ± 1074 ml, P = 0.189).
- Carperitide and nicorandil were differentially effective in improving hemodynamics in AHFS patients.