Adenosine improves post-procedural coronary flow but not clinical outcomes in patients with acute coronary syndrome: A meta-analysis of randomized trials
Atherosclerosis,  Evidence Based Medicine  Clinical Article

Navarese EP et al. – This meta–analysis shows that adenosine adjunctive therapy does not improve survival nor reduce the rates of re–MI and heart failure (HF) symptoms in patients with acute coronary syndromes (ACS) treated with PCI or thrombolysis. The beneficial effect on post–procedural coronary flow was not associated with consistent advantages on clinical outcomes.

Methods
  • Medline/CENTRAL/EMBASE and Google Scholar database were scanned.
  • The meta–analysis included ten RCTs (N=3821).
  • All–cause mortality was chosen as primary endpoint.
  • Secondary endpoints were re–infarction (MI), heart failure (HF) symptoms (NYHA class III/IV), no–reflow (defined as TIMI 0 flow) and >50% ST–resolution.

Results
  • Adenosine compared to placebo was associated with a significant reduction of post–procedural no–reflow (OR [95% CI]=0.25 [0.08–0.73], p=0.01); however, at a median follow–up of 6 months, prior treatment with adenosine did not confer significant benefits in terms of reduction of mortality (ORFixed [95% CI]=0.87 [0.69–1.09], p=0.23), as well as re–MI (p=0.80), HF symptoms (p=0.44) and ST–resolution (p=0.09).
  • Separate analyses conducted in the subgroups of ST–elevation MI patients treated with either PCI or thrombolysis confirmed the findings found in the overall population.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...

Your Unread Messages in Cardiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

<

Most Popular Cardiology Articles

Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heartmore

Make smarter career moves with less time.

Sign up for our free job placement service today and have a dedicated career consultant help locate the right physician job for you!
Click Here for more information.

Get Started Now!

Free-of-charge, no obligation.

Terms and Conditions For M3 Career Consult

By registering with the M3 Career Consult service you authorize M3 USA Corporation to represent you in your job search. The following is a summary of the terms of our service and our mutual obligations to help you find a job:

  • You designate M3 to act as your agent and represent you in your job search;
  • You will not pay us for this service
  • You will advise us of any companies or positions to which you apply or have applied;
  • You will advise us if you believe you are not capable of performing a position for which we submit you, or for which you interview;
  • You will keep all information we provide you about companies or positions strictly confidential;
  • You will promptly provide us with information we request of you;
  • You will make yourself reasonably available for phone, video and in-person conversations and interviews;
  • You will be truthful in all of your communications with us; and
  • You will advise us if anything above changes.
 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List