mdlinx mdlinx
Latest (30) Full Text Articles (3243) Focus on Intervention Article Summary

The role of statin therapy in the prevention of atrial fibrillation: a meta-analysis of randomized controlled trials
British Journal of Clinical Pharmacology,  Clinical Article

Fang WT et al. – Statin therapy was significantly associated with a decreased risk of incidence or recurrence of atrial fibrillation (AF). Heterogeneity was explained by differences in statin types, patient population and surgery types. Benefit of statin therapy seemed more markedly in secondary prevention than primary prevention.

  • Meta analysis of randomized, controlled trials with use of statins on incidence or recurrence of AF was performed.

  • 20 studies with 23577 patients were included in the analysis.
  • 7 studies investigated the use of statins in patients with AF, 11 studies investigated the primary prevention of statins in patients without AF, and 2 studies investigated mix population patients.
  • Incidence or recurrence of AF occurred in 1543 patients.
  • Overall, statins therapy was significantly associated with a decreased risk of AF compared with control (OR 0.49, 95% CI 0.37 to 0.65, p <0.00001).
  • Beneficial effect was found in atorvastatin subgroup and simvastatin subgroup, but not found in pravastatin subgroup and rosuvastatin subgroup.
  • Benefit of statin therapy seemed more markedly in secondary prevention (OR 0.34, 95% CI 0.18 to 0.64, p<0.0008) than primary prevention (OR 0.54, 95% CI 0.40 to 0.74, p< 0.0001).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Cardiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Cardiology Articles

Last month's top read Top Articles of 2013

Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heartmore

Other Topics in Cardiology

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool


Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More