Effects of statin therapy on non-calcified coronary plaque assessed by 64-slice computed tomography
International Journal of Cardiology,  Clinical Article

Kitagawa T et al. – This Computed tomography angiography (CTA) findings demonstrate that low–density NCALs occur less frequently in patients with intensive statin pre–treatment. A high LDL–C/HDL–C ratio is also associated with larger numbers of low–density NCALs.

Methods
  • Among 493 consecutive patients who underwent coronary CTA, authors enrolled 114 patients with NCALs.
  • Authors divided the patients into three groups according to preceding statin therapy: intensive statins (IS, n=24), moderate statins (MS, n=26), and no statin (NS, n=64).
  • The vulnerability of each NCAL was evaluated by density (low–density plaque defined as CT density ≤38HU), positive remodeling (remodeling index>1.05), and the presence of adjacent spotty calcification.

Results
  • Percentages of patients in the IS, MS, and NS groups with low–density NCALs were 46%, 58%, and 80%, respectively (p=0.009) and positive remodeling NCALs were 54%, 58%, and 75%, respectively (p=0.10).
  • Authors also found an inverse correlation between serum LDL–C level and the minimum plaque CT density.
  • According to the regression equation, a CT density of 38HU corresponded with LDL–C of 100mg/dl.
  • The number of low–density plaques was positively correlated with low–density to high–density lipoprotein cholesterol ratio (LDL–C/HDL–C).
  • An LDL–C/HDL–C>2.5 independently predicted multiple low–density plaques (OR 2.39 [95%CI: 1.28–4.86], p<0.001).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Cardiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Cardiology Articles

1 Rivaroxaban vs. vitamin K antagonists for cardioversion in atrial fibrillation European Heart Journal, September 16, 2014    Clinical Article

2 Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease The American Journal of Cardiology, September 5, 2014    Clinical Article

3 Efficacy of dronedarone versus propafenone in the maintenance of sinus rhythm in patients with atrial fibrillation after electrical cardioversion Clinical Therapeutics, August 19, 2014    Clinical Article

4 Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid Journal of Thrombosis and Haemostasis, September 25, 2014    Clinical Article

5 Discontinuation of smokeless tobacco and mortality risk after myocardial infarction Circulation, July 25, 2014    Clinical Article

6 Prasugrel vs. clopidogrel in acute coronary syndrome patients treated with prasugrel Journal of Clinical Pharmacy and Therapeutics, September 24, 2014    Clinical Article

7 Statin therapy improves long-term survival in non-ischaemic cardiomyopathy: a pooled analysis of 4500 patients Heart, Lung, and Circulation, August 15, 2014    Clinical Article

8 The use of statins to prevent postoperative atrial fibrillation after coronary artery bypass grafting: a meta-analysis of 12 studies Journal of Cardiovascular Pharmacology, September 18, 2014    Review Article

9 Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease The American Journal of Cardiology, August 28, 2014    Clinical Article

10 Minimally invasive direct coronary bypass grafting versus percutaneous coronary intervention for single-vessel disease: A meta-analysis of 2885 patients European Journal of Cardio-Thoracic Surgery, August 14, 2014    Evidence Based Medicine    Review Article    Clinical Article

11 Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials Hypertension, September 29, 2014    Evidence Based Medicine    Review Article

12 Beta-blockers in heart failure with preserved ejection fraction: A meta-analysis Heart Failure Reviews, July 28, 2014    Evidence Based Medicine    Review Article    Clinical Article

13 High-intensity statin therapy alters the natural history of diabetic coronary atherosclerosis: insights from saturn Diabetes Care, September 12, 2014    Clinical Article

14 Effects of lipophilic statins for heart failure: a meta-analysis of 13 randomised controlled trials Heart, Lung, and Circulation, September 15, 2014    Evidence Based Medicine    Review Article    Clinical Article

15 Efficacy and safety of the new oral anticoagulants dabigatran, rivaroxaban, apixaban, and edoxaban in the treatment and secondary prevention of venous thromboembolism: a systematic review and meta-analysis of phase III trials European Journal of Vascular and Endovascular Surgery, September 12, 2014    Evidence Based Medicine    Review Article    Clinical Article

16 Egg consumption and cardiovascular disease among diabetic individuals: a systematic review of the literature Full Text Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, July 30, 2014    Free full text    Review Article

17 Impact of access on TAVI procedural and midterm follow-up: A meta-analysis of 13 studies and 10,468 patients Journal of Interventional Cardiology, September 23, 2014    Review Article    Clinical Article

18 A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes from a randomised controlled trial The Lancet, September 19, 2014    Evidence Based Medicine    Clinical Article

19 Thiazide-like/calcium channel blocker agents: a major combination for hypertension management American Journal of Cardiovascular Drugs, September 2, 2014    Clinical Article

20 Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial European Heart Journal, September 10, 2014    Clinical Article

Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heartmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close