Vitamin D Status Is Associated With Arterial Stiffness and Vascular Dysfunction in Healthy Humans Full Text
JACC - Journal of the American College of Cardiology, 06/28/2011
Al Mheid I et al. – Vitamin D insufficiency is associated with increased arterial stiffness and endothelial dysfunction in the conductance and resistance blood vessels in humans, irrespective of traditional risk burden. These findings provide impetus for larger trials to assess the effects of vitamin D therapy in cardiovascular disease.Methods
- Authors measured serum 25–OH D in 554 subjects.
- Endothelial function was assessed as brachial artery flow–mediated dilation, and microvascular function was assessed as digital reactive hyperemia index.
- Carotid–femoral pulse wave velocity and radial tonometry–derived central augmentation index and subendocardial viability ratio were measured to assess arterial stiffness.
- Mean 25–OH D was 31.8 ± 14 ng/ml.
- After adjustment for age, sex, race, body mass index, total cholesterol, low–density lipoprotein, triglycerides, C–reactive protein, and medication use, 25–OH D remained independently associated with flow–mediated vasodilation (β = 0.1, p = 0.03), reactive hyperemia index (β= 0.23, p < 0.001), pulse wave velocity (β = –0.09, p = 0.04), augmentation index (β = –0.11, p = 0.03), and subendocardial viability ratio (β = 0.18, p = 0.001).
- In 42 subjects with vitamin D insufficiency, normalization of 25–OH D at 6 months was associated with increases in reactive hyperemia index (0.38 ± 0.14, p = 0.009) and subendocardial viability ratio (7.7 ± 3.1, p = 0.04), and a decrease in mean arterial pressure (4.6 ± 2.3 mm Hg, p = 0.02).