mdlinx mdlinx
Latest (38) Full Text Articles (3243) Focus on Vascular Disorders-Stroke Article Summary

Cardiovascular Event Reduction and Adverse Events Among Subjects Attaining Low-Density Lipoprotein Cholesterol <50 mg/dl With Rosuvastatin
JACC - Journal of the American College of Cardiology,

Hsia J et al. - Among adults with LDL-C <130 mg/dl and high-sensitivity C-reactive protein 2 mg/l, rosuvastatin-allocated participants attaining LDL-C <50 mg/dl had a lower risk of cardiovascular events without a systematic increase in reported adverse events.

Methods
  • A cohort of 17,802 apparently healthy men and women with high-sensitivity C-reactive protein 2 mg/l and LDL-C <130 mg/dl were randomly allocated to rosuvastatin 20 mg daily or placebo, and followed up for all-cause mortality, major cardiovascular events, and adverse events.
  • In a post-hoc analysis, participants allocated to rosuvastatin were categorized as to whether or not they had a follow-up LDL-C level <50 mg/dl.

Results
  • A median follow-up of 2 years (range up to 5 years) was conducted
  • Rates of the primary trial endpoint were 1.18, 0.86, and 0.44 per 100 person-years in the placebo group (n = 8,150) and rosuvastatin groups without LDL-C <50 mg/dl (n = 4,000) or with LDL-C <50 mg/dl (n = 4,154), respectively (fully-adjusted hazard ratio: 0.76; 95% confidence interval: 0.57 to 1.00 for subjects with no LDL-C <50 mg/dl vs. placebo and 0.35, 95% confidence interval: 0.25 to 0.49 for subjects attaining LDL-C <50 mg/dl; p for trend <0.0001)
  • For all-cause mortality, corresponding event rates were 0.67, 0.65, and 0.39 (p for trend = 0.004)
  • Rates of myalgia, muscle weakness, neuropsychiatric conditions, cancer, and diabetes mellitus were not significantly different among rosuvastatin-allocated participants with and without LDL-C <50 mg/dl

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Cardiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Cardiology Articles

Last month's top read Top Articles of 2013

1 Vitamin D deficiency and coronary artery disease: A review of the evidence American Heart Journal, March 5, 2014    Review Article

2 Medical therapy versus implantable cardioverter -defibrillator in preventing sudden cardiac death in patients with left ventricular systolic dysfunction and heart failure: A meta-analysis of >35,000 patients International Journal of Cardiology, March 17, 2014    Clinical Article

3 Atenolol versus non-atenolol beta-blockers for the treatment of hypertension: a meta analysis Canadian Journal of Cardiology, February 10, 2014    Evidence Based Medicine    Review Article    Clinical Article

4 Beta blockers in hypertension: studies and meta-analyses over the years Canadian Journal of Cardiology, March 21, 2014    Evidence Based Medicine    Review Article    Clinical Article

5 Serum levels of fetuin-A, osteoprotegerin and osteopontin in patients with coronary artery disease: Effects of Statin (HMGCoA-Reductase Inhibitor) Therapy Clinical Drug Investigation, March 3, 2014    Clinical Article

6 Efficacy and safety of high dose versus low dose furosemide with or without dopamine infusion: The Dopamine in Acute Decompensated Heart Failure II (DAD-HF II) Trial International Journal of Cardiology, February 18, 2014    Clinical Article

7 Comparative coronary risks of apixaban, rivaroxaban and dabigatran: A meta-analysis and adjusted indirect comparison British Journal of Clinical Pharmacology, March 13, 2014    Evidence Based Medicine

8 Rivaroxaban and dabigatran in patients undergoing catheter ablation of atrial fibrillation EP Europace, March 4, 2014    Clinical Article

9 Aspirin use in heart failure Circulation: Heart Failure, March 20, 2014    Clinical Article

10 Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: A randomized, placebo-controlled trial Full Text Nutrition Journal, November 15, 2013    Free full text    Clinical Article

11 Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting The American Journal of Cardiology, January 30, 2014    Evidence Based Medicine    Review Article    Clinical Article

12 What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice European Journal of Preventive Cardiology, March 18, 2014    Evidence Based Medicine    Review Article    Clinical Article

13 An unusual cause of dyspnoea in a young man European Heart Journal, March 3, 2014

14 Update on the efficacy of statin treatment in Acute Coronary Syndromes European Journal of Clinical Investigation, March 14, 2014    Review Article    Clinical Article

15 Application of new cholesterol guidelines to a population-based sample New England Journal of Medicine, March 24, 2014    Evidence Based Medicine    Clinical Guideline    Clinical Article

16 Long-term coffee consumption and risk of cardiovascular disease Circulation, February 11, 2014    Evidence Based Medicine    Review Article    Clinical Article

17 Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: Observations from the ARISTOTLE trial European Heart Journal, February 28, 2014    Clinical Article

18 High diet quality is associated with a lower risk of cardiovascular disease and all-cause mortality in older men The Journal of Nutrition, March 3, 2014    Clinical Article

19 Effect of switch to the highest dose of rosuvastatin versus add-on-statin fenofibrate versus add-on-statin nicotinic acid/laropiprant on oxidative stress markers in patients with mixed dyslipidemia Cardiovascular Therapeutics, March 26, 2014    Clinical Article

20 Dietary patterns, Mediterranean diet, and cardiovascular disease Current Opinion in Lipidology, March 7, 2014    Review Article

Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heartmore

Other Topics in Cardiology

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close