The role of niacin in raising high-density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol: Baseline characteristics of study participants. The Atherothrombosis Intervention in Metabolic syndrome with low HDL/high triglycerides: Impact on Global Health outcomes (AIM-HIGH) trial
American Heart Journal,  Clinical Article

This study was designed to determine whether there is incremental clinical benefit of niacin in reducing cardiovascular events in patients who have attained optimal on-treatment levels of low-density lipoprotein cholesterol (LDL-C) with a statin.

Methods
  • Between 2006 and 2010, 8,162 individuals signed consent to be screened, 4,275 began study drug run-in, and 3,414 were randomized to treatment.
  • Mean age at entry was 64 ± 9 years, 85% were men, and 92% were white.
  • All study participants had established CV disease and atherogenic dyslipidemia.
  • Participants received simvastatin (or simvastatin plus ezetimibe) at a dose sufficient to maintain LDL-C at 40 - 80 mg/dL (1.03-2.07 mmol/L) and were randomized to receive extended-release niacin or matching placebo.
  • The primary end point is time to the first occurrence of coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, hospitalization for acute coronary syndrome or symptom-driven coronary or cerebral revascularization with average follow-up of 4.1 years.

Results
  • Risk factors were prevalent with 34% having diabetes; 71%, hypertension; and 81%, metabolic syndrome.
  • Most participants had coronary artery disease (92%), whereas 11% had peripheral arterial disease; and 12%, cerebrovascular disease.
  • Previous coronary revascularization occurred in 82%, and 54% reported a prior myocardial infarction.
  • Among participants on a statin at entry (94%), mean baseline LDL-C was 71 mg/dL (1.84 mmol/L); mean high-density lipoprotein cholesterol (HDL-C), 34.9 mg/dL (0.90 mmol/L); and median triglycerides, 161 mg/dL (1.82 mmol/L).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Cardiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Cardiology Articles

1 Rivaroxaban vs. vitamin K antagonists for cardioversion in atrial fibrillation European Heart Journal, September 16, 2014    Clinical Article

2 Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials Hypertension, September 29, 2014    Evidence Based Medicine    Review Article

3 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

4 A systematic review of statin-induced muscle problems in clinical trials American Heart Journal, October 7, 2014    Review Article

5 Thromboembolic risk in 16 274 atrial fibrillation patients undergoing direct current cardioversion with and without oral anticoagulant therapy EP Europace, September 19, 2014    Clinical Article

6 Effect of statins in preventing contrast-induced nephropathy: an updated meta-analysis Coronary Artery Disease, October 2, 2014    Clinical Article

7 Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease The American Journal of Cardiology, September 5, 2014    Clinical Article

8 Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: Final baseline characteristics of the IMPROVE-IT study population American Heart Journal, October 6, 2014    Clinical Article

9 Effect of Nicorandil in patients with heart failure: A systematic review and meta-analysis Cardiovascular Therapeutics, October 17, 2014    Evidence Based Medicine    Review Article    Clinical Article

10 New oral anticoagulants for the treatment of venous thromboembolism: understanding differences and similarities Drugs, October 10, 2014    Review Article

11 The effect of indapamide versus hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: Results of a randomized trial American Heart Journal, October 1, 2014    Clinical Article

12 Effect of different dose aspirin on coronary artery lesions in the acute phase of Kawasaki disease JACC - Journal of the American College of Cardiology, October 21, 2014    Clinical Article

13 Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid Journal of Thrombosis and Haemostasis, September 25, 2014    Clinical Article

14 Efficacy of dronedarone versus propafenone in the maintenance of sinus rhythm in patients with atrial fibrillation after electrical cardioversion Clinical Therapeutics, August 19, 2014    Clinical Article

15 Efficacy and safety of apixaban compared with warfarin for stroke prevention in patients with atrial fibrillation from East Asia: A subanalysis of the apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial American Heart Journal, October 13, 2014    Clinical Article

16 Tea consumption is inversely related to 5-year blood pressure change among adults in Jiangsu, China: A cross-sectional study Full Text Nutrition Journal, October 24, 2014    Free full text    Clinical Article

17 Endovascular versus medical therapy for atherosclerotic renovascular disease Current Atherosclerosis Reports, October 23, 2014    Clinical Article

18 Starting primary prevention earlier with statins The American Journal of Cardiology, October 15, 2014    Clinical Article

19 Ischemic postconditioning versus remote ischemic conditioning in patients treated with primary percutaneous coronary intervention: A Bayesian network meta-analysis JACC - Journal of the American College of Cardiology, October 16, 2014    Clinical Article

20 Prasugrel vs. clopidogrel in acute coronary syndrome patients treated with prasugrel Journal of Clinical Pharmacy and Therapeutics, September 24, 2014    Clinical Article

Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heartmore