Circulating levels of carboxy-methyl-lysine (CML) are associated with hip fracture risk: the cardiovascular health study

Journal of Bone and Mineral Research, 10/29/2013

Advanced glycation end products (AGE) in bone tissue are associated with impaired biomechanical properties and increased fracture risk. Here the authors examine whether serum levels of the AGE carboxy–methyl–lysine (CML) are associated with risk of hip fracture. The authors conclude that increasing levels of CML are associated with hip fracture risk in older adults, independent of hip BMD. These results implicate AGE in the pathogenesis of hip fractures.

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