Dietary patterns derived from principal component- and k-means cluster analysis: Long-term association with coronary heart disease and stroke
Nutrition, Metabolism & Cardiovascular Diseases, 05/31/2012Stricker MD et al.
PCA and k–means cluster analysis (KCA) found similar underlying patterns with comparable associations with CHD and stroke risk. A prudent pattern reduced the risk of CHD and stroke.
The study was conducted in the EPIC–NL cohort that consists of 40,011 men and women.
Baseline dietary intake was measured using a validated food–frequency questionnaire.
Food items were consolidated into 31 food groups.
Occurrence of CHD and stroke was assessed through linkage with registries.
After 13 years of follow–up, 1,843 CHD and 588 stroke cases were documented.
Both PCA and KCA extracted a prudent pattern (high intakes of fish, high–fiber products, raw vegetables, wine) and a western pattern (high consumption of French fries, fast food, low–fiber products, other alcoholic drinks, soft drinks with sugar) with small variation between components and clusters.
The prudent component was associated with a reduced risk of CHD (HR for extreme quartiles: 0.87; 95%–CI: 0.75–1.00) and stroke (0.68; 0.53–0.88).
The western component was not related to any outcome.
The prudent cluster was related with a lower risk of CHD (0.91; 0.82–1.00) and stroke (0.79; 0.67–0.94) compared to the western cluster.
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