Preoperative statin therapy is not associated with a decrease in the incidence of delirium after cardiac operations

Annals of Thoracic Surgery, 05/09/2012

Preoperative statins were not associated with a decreased incidence of delirium in patients undergoing coronary revascularization.


  • The study enrolled 4,659 consecutive patients (21% women; age, 67.8 ± 9.2 years) undergoing coronary artery bypass grafting.
  • A propensity score–based optimal–matching algorithm was used to match 1,577 patients receiving preoperative statins with a control group (1:1).
  • Patients were screened for delirium in the intensive care unit according to the Confusion Assessment Method for the intensive care unit.


  • Delirium affected 89 patients (3%), and preoperative statin administration was not multivariably associated with a decreased incidence of delirium (odds ratio, 1.52; 95% confidence interval, 0.97 to 2.37; p = 0.18) and was also unrelated to a delirium decrease in patient subgroups undergoing isolated coronary artery bypass grafting (odds ratio, 1.31; 95% confidence interval, 0.68 to 2.52; p = 0.51) or combined valvular procedures (odds ratio, 1.72; 95% confidence interval, 0.96 to 3.07, p = 0.08).
  • Similar results were observed for age groups and cardiopulmonary bypass durations.
  • Patients affected by postoperative delirium experienced a longer hospital stay (25th to 75th percentile) of 11 (7 to 18 days) vs 7 days (7 to 8 days, p < 0.001) and 12% hospital mortality vs 1% (p < 0.001).

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