Changes in Small Dense Low-Density Lipoprotein Levels Following Acute Coronary Syndrome

Angiology, 05/04/2012

Patients with acute coronary syndrome (ACS) have higher concentration of small dense LDL (sdLDL) compared with the controls.


  • The authors compared baseline sdLDL levels between healthy controls and patients with acute coronary syndrome (ACS).
  • Blood samples were taken from patients diagnosed with myocardial infarction ([MI] n = 104) and unstable angina ([UA] n = 100).


  • Both sdLDL and high–sensitivity C–reactive protein (hsCRP) levels were determined on admission and in the next 24 hours after the onset of symptoms.
  • Baseline concentration of sdLDL was significantly higher in patients presenting with ACS than controls (P < .05).
  • In the 24 hours following ACS, the sdLDL levels decreased insignificantly in both groups of patients with ACS (P > .05).
  • The changes in sdLDL values were not significantly different between MI and UA participants (P > .05).

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