Evaluation of the effects of urotensin ii and soluble epoxide hydrolase inhibitor on skin microvessel tone in healthy controls and heart failure patients

Cardiovascular Therapeutics, 04/27/2012

The presence of HF appeared to abrogate the vasodilator responsiveness of sEH inhibitor. These results suggest an important role for both UII and sEH in vascular regulation and that sEH may be involved in mediating UII effects. Furthermore, the study highlights the therapeutic potential of sEH inhibitors for the treatment of HF.

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