Hemodynamic characteristics and predictors of pulmonary hypertension in patients with sickle cell disease

The American Journal of Cardiology, 04/25/2012

These results suggest that the mild elevation in tricuspid regurgitation jet velocitie (TRV) often observed in patients with sickle cell disease is rarely associated with a high pulmonary vascular resistance and that multiple factors—including the compensatory high output state associated with anemia, pulmonary venous hypertension, and pulmonary vasculopathy—can contribute to an elevated pulmonary arterial pressure in these patients.

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