Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis

Atherosclerosis, 04/13/2012

Ikeda S et al. – The findings indicate that the lymphotoxin–(alpha) (LTA) and LGALS2 polymorphisms affect the subclinical phenotype of the coronary artery, which predisposes to the incidence of myocardial infarction.

Methods

  • The authors investigated the correlation between polymorphisms of the LTA, LGALS2, and PSMA6 genes and the severity of pathological coronary stenosis index (CSI) and MI in 1503 consecutive autopsy cases of Japanese elderly patients.

Results

  • The polymorphisms LTA rs1041981 and LGALS2 rs7291467 were associated with CSI with odds ratios of 1.54 (95% CI, 1.17–2.01; AA+CA over CC) and 1.62 (95% CI, 1.11–2.37; TT over CC+CT), respectively.
  • PSMA6 rs1048990 was not associated with CSI. None of the SNPs was associated with MI in the sample.

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