Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials

Lipids in Health and Disease, 04/05/2012

The lipid modulating effects of vitamin D supplementation should be further investigated though large–scale, randomized trials with adequate doses which can effectively elevated the active form of vitamin D in plasma and with proper population which has hyperlipemia as an inclusion criterion.


  • Authors conducted a meta–analysis of randomized controlled trials that evaluated the effects of vitamin D supplementation on blood lipids.
  • A systematic literature search was conducted via MEDLINE, Cochrane library, and EMBASE for randomized controlled clinical trials assessing the effects of vitamin D supplementation on lipids.
  • The mean change in total cholesterol (TC), low–density lipoprotein cholesterol (LDL–C), high–density lipoprotein cholesterol (HDL–C) and triglycerides (TG) from baseline was treated as a continuous variable.
  • In all, 12 clinical trials consisting of 1346 participants were included in the analysis.
  • The pooled estimate of effect for vitamin D supplementation on LDL–C was 3.23 mg/dl (95% confidence interval, 0.55 to 5.90 mg/dl).


  • No statistically significant effects for vitamin D supplementation were observed for TC, HDL–C and TG (differences in means were 1.52 mg/dl (1.42 to 4.46 mg/dl), –0.14 mg/dl (0.99 to 0.71 mg/dl) and 1.92 mg/dl (7.72 to 3.88 mg/dl) respectively).

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