Statins and their influence on brain cholesterol

Journal of Clinical Lipidology, 10/11/2011

Better understanding of the effects of statins on brain metabolism becomes more important because many studies bring evidence of a possible link between cholesterol and neurodegeneration.

Methods

  • The MEDLINE database.

Results

  • According to the data reported thus far, statins may influence brain cholesterol metabolism directly (because they are able to penetrate BBB no matter whether they are hydrophilic or lipophilic) and also indirectly (by lowering plasma cholesterol).
  • Although the definite mechanism is not known yet, it becomes obvious that statins do not only influence peripheral but also central cholesterol pool.

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