Effects of statin therapy on non-calcified coronary plaque assessed by 64-slice computed tomography
International Journal of Cardiology, 07/20/2011Kitagawa T et al.
This Computed tomography angiography (CTA) findings demonstrate that low–density NCALs occur less frequently in patients with intensive statin pre–treatment. A high LDL–C/HDL–C ratio is also associated with larger numbers of low–density NCALs.
Among 493 consecutive patients who underwent coronary CTA, authors enrolled 114 patients with NCALs.
Authors divided the patients into three groups according to preceding statin therapy: intensive statins (IS, n=24), moderate statins (MS, n=26), and no statin (NS, n=64).
The vulnerability of each NCAL was evaluated by density (low–density plaque defined as CT density ≤38HU), positive remodeling (remodeling index>1.05), and the presence of adjacent spotty calcification.
Percentages of patients in the IS, MS, and NS groups with low–density NCALs were 46%, 58%, and 80%, respectively (p=0.009) and positive remodeling NCALs were 54%, 58%, and 75%, respectively (p=0.10).
Authors also found an inverse correlation between serum LDL–C level and the minimum plaque CT density.
According to the regression equation, a CT density of 38HU corresponded with LDL–C of 100mg/dl.
The number of low–density plaques was positively correlated with low–density to high–density lipoprotein cholesterol ratio (LDL–C/HDL–C).
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