Vitamin D intake and risk of cardiovascular disease in US men and women

American Journal of Clinical Nutrition, 06/10/2011

A higher intake of vitamin D is associated with a lower risk of cardiovascular disease (CVD) in men but not in women.


  • In the Nurses’ Health Study (1984–2006) and the Health Professionals Follow–Up Study (1986–2006)–consisting of 74,272 women and 44,592 men, respectively, who were free of CVD and cancer at baseline–we prospectively examined the association between vitamin D intake and incident CVD.


  • Over a total of 2,280,324 person–years of follow–up, authors identified 9886 incident cases of coronary heart disease and stroke.
  • After multivariate adjustment for age and other CVD risk factors, a higher total vitamin D intake (from foods and supplements) was associated with a decreased risk of CVD in men but not in women; the relative risks (95% CIs) for a comparison of participants who met the Dietary Reference Intake of vitamin D (>=600 IU/d) with participants whose vitamin D intake was <100 IU/d were 0.84 (0.72, 0.97; P for trend = 0.009) for men and 1.02 (0.89, 1.17; P for trend = 0.12) for women.

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