Trends in utilization of lipid- and blood pressure-lowering agents and goal attainment among the U.S. diabetic population, 1999-2008

Cardiovascular Diabetology, 04/25/2011

Kuznik A et al. – The proportion of diabetic individuals taking lipid– and blood pressure(BP)–lowering agents has increased significantly in recent years. However, while there has been a significant improvement in low–density lipoprotein cholesterol(LDL–C) goal attainment, nearly one–half of all U.S. adults with diabetes are not at recommended LDL–C or BP treatment goals.


  • 9,167 men and nonpregnant women aged [greater than or equal to]20 years were identified from the fasting subsample of the 1999–2008 National Health and Nutritional Examination Survey
  • Diabetes was identified in 1,214 participants by self report, self–reported use of insulin or oral medications for diabetes, or fasting glucose [greater than or equal to]6.99 mmol/L (126 mg/dL)


  • The prevalence of diagnosed or undiagnosed diabetes increased significantly over the past decade, from 7.4% in 1999–2000 to 11.9% in 2007–2008 (P=0.0007)
  • During this period, the use of lipid–lowering agents by participants with diabetes increased from 19.5% to 42.2% (P<0.0001), and the proportion at LDL–C goal increased from 29.7% to 54.4% (P<0.0001)
  • Although there was a significant increase in antihypertensive medication use (from 35.4% to 58.9%; P<0.0001), there was no significant change in the proportion of participants at BP goal (from 47.6% to 55.1%; P=0.1333) or prevalence of hypertension (from 66.6% to 74.2%; P=0.3724)

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