The relationship of vitamin D deficiency to statin myopathy

Atherosclerosis, 03/28/2011

The review suggests that some but not all statins increase 25(OH) D levels. It is presently premature to recommend vitamin D supplementation as treatment for statin associated muscle complaints in the absence of low vitamin D levels although such supplementation could be tried in patients with deficient or reduced vitamin D levels.


  • Authors identified English language articles relating statins, vitamin D and statin myopathy via a PubMed search through July 2010.
  • Articles pertinent to the topic were reviewed in detail.


  • 2 cross sectional studies have associated vitamin D deficiency with statin–associated myalgias, and suggested that that increasing vitamin D levels can reverse the myalgia.

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