Initial hypertension treatment: one combination fits most

Journal of the American Society of Hypertension, 03/23/2011

Brook RD et al. - Authors outline a novel algorithm of starting initial therapy with a single tablet containing amlodipine + benazepril in most patients with hypertension regardless of stage or comorbidities. This streamlined approach is likely to yield an overall positive risk/benefit ratio.


  • Authors reviewed published studies related to the efficacy and efficiency of starting combination antihypertensive treatment versus mono-therapy.


  • The evidence supports that initial combination therapy is more effective for many outcomes (ie, reaching blood pressure targets, rapidity of control, patient adherence, and cardiovascular protection assessed by surrogate markers).
  • The few available published clinical trials and observational studies support that the amlodipine + an angiotensin-converting enzyme inhibitor combination may be the most effective for reducing cardiovascular events.

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