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The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature

Qin Z – A potential trajectory is to use this cell line to study the novel molecular mechanisms in monocytes and macrophages in relation to the physiology and pathophysiology of the cardiovascular system, however, the conclusion of studies employing THP–1 cells requires further verification using primary cells and/or in vivo models to be generalized to monocytes and macrophages. [more...]