Progression of carotid atherosclerosis in patients with systemic lupus erythematosus
Clinical Rheumatology, May 1, 2013
Telles RW et al. - The progression of carotid atherosclerosis in lupus patients is frequently encountered, and it is determined by both traditional and nontraditional risk factors. The progression of carotid atherosclerosis in lupus patients is frequently encountered, and it is determined by both traditional and nontraditional risk factors. Methods Of the 181 patients initially included in the study, 157 patients were reevaluated after 39(37-42)months. The progression of ...
Overview of vasculitis and vasculopathy in rheumatoid arthritis--something to think about
Clinical Rheumatology, May 7, 2013
Radic M et al. - Advances in treatment of rheumatoid arthritis with disease-modifying biologic and nonbiologic agents will probably continue to reduce the incidence of vasculitis. Since the goal of treatment for rheumatoid arthritis is to decrease inflammatory burden, successful treatment may theoretically reduce the risk of accelerated atherosclerosis.
The vasculature plays a crucial role in inflammation and atherosclerosis associated with the pathogenesis of rheumatoid ...
Diagnosis and management of carotid atherosclerosis
British Medical Journal, March 22, 2013
Thapar A. et al. - This review discusses the risk factors, clinical presentation, investigations, and treatment options for symptomatic and asymptomatic carotid atherosclerosis. All references to stenosis use consensus North American Symptomatic Carotid Endarterectomy Trial (NASCET) measurements.1 All recommendations reflect current UK guidelines, unless stated otherwise. Carotid atherosclerosis is a pathological thickening of the common or internal carotid intima, typically into ...
Interactions between inflammation and lipid metabolism: Relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis
Atherosclerosis, March 25, 2013
van Diepen J.A. et al.- The interplay between lipid metabolism and inflammation at multiple levels in metabolic active tissues may exacerbate the development of atherosclerosis, and is discussed in this review.
Dyslipidemia and inflammation are well known causal risk factors the development of atherosclerosis
Cholesterol, fatty acids and modified lipids can directly activate inflammatory pathways.
In addition, circulating (modified) lipoproteins modulate the activity of ...
Atherosclerotic Changes in Common Carotid Artery, Common Femoral Artery, and Ascending Aorta/Aortic Arch in Candidates for Coronary Artery Bypass Graft Surgery
Angiology, March 27, 2013
Tarzamni M.K. et al.- This study assessed the association between common carotid and common femoral artery intima–media thickness (ccIMT and cfIMT, respectively), histopathologic severity of atherosclerosis in the ascending aorta/aortic arch, and the extent of coronary artery disease (CAD) in 150 candidates for elective coronary artery bypass grafting (CABG).In conclusion, both cfIMT and atherosclerosis of ascending aorta/aortic arch are independent predictors of CAD extent. However, ...
Immunity, atherosclerosis and cardiovascular disease
BMC Medicine, May 7, 2013
Frostegard J - atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic inflammatory condition with immune competent cells in lesions producing mainly pro-inflammatory cytokines. Dead cells and oxidized forms of low density lipoproteins (oxLDL) are abundant. The major direct cause of CVD appears to be rupture of atherosclerotic plaques. oxLDL has proinflammatory and immune-stimulatory properties, causes cell death at higher concentrations and contains ...
The effect of HIV infection on atherosclerosis and lipoprotein metabolism: A one year prospective study
Atherosclerosis, May 13, 2013
Rose H et al. - HIV infection is associated with dyslipidaemia and increased risk of cardiovascular disease. The effects of HIV infection and antiretroviral treatment on surrogate markers of atherosclerosis, and lipoprotein metabolism were evaluated in a 12 month prospective study. This study did not find evidence for rapid progression of subclinical atherosclerosis and deterioration of dyslipidaemia in HIV patients within 1 year.
Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study
Atherosclerosis, May 15, 2013
Lim S et al. - Common variants at the 2q36.3-IRS1 locus are associated with insulin resistance (IR), type 2 diabetes (T2D) and coronary artery disease (CAD) in large-scale association studies. The authors tested the hypothesis that variants at this locus are associated with subclinical atherosclerosis traits. Common variants at the 2q36.3-IRS1 locus were not associated with subclinical atherosclerosis traits in this study which was adequately powered to find ...
Competing Cardiovascular Outcomes Associated With Subclinical Atherosclerosis (from the Multi-Ethnic Study of Atherosclerosis)
The American Journal of Cardiology, May 16, 2013
Desai CS et al. - Subclinical atherosclerosis measured by coronary artery calcium (CAC) is associated with increased risk for multiple cardiovascular disease (CVD) outcomes and non-CVD death simultaneously. At all levels of CAC, coronary heart disease was the most common first CVD event, and this analysis represents a novel approach to understanding the temporal sequence of cardiovascular events associated with atherosclerosis.
Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes
Cardiovascular Diabetology, February 12, 2013
Sheng L et al. - This study aimed to investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes. Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.
Authors performed a cross-sectional community-based study in metropolitan area.
Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women.