Rho-associated kinase activity is a biomarker for cardiovascular events
As reported in Hypertension, rho-associated kinase activity is an independent predictor of cardiovascular events. The study involved 633 patients undergoing routine health screening examinations with a median follow-up of 42 months. There were 29 cardiovascular-related deaths, 2 myocardial infarctions, 20 revascularizations, 15 strokes, and 17 hospitalizations for heart failure. The HRs for first cardiovascular event, death, stroke, and revascularization were 2.19, 2.57, 2.14, and 2.68, respectively.
Relationship benefit in women with IHD
As reported in BMC Medicine, women who were married or living with a partner had a decreased risk of mortality (RR=0.72) after the first ischemic heart disease (IHD) event compared to women who were not married or living with a partner. The study involved 734626 women with no history of IHD who were followed for 8.6 y; there were 30747 women with a first IHD event and 2148 deaths.
Muscle strength in adolescence decreases CVD risk
As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).