The ventral striatum is implicated in the analgesic effect of mood changes
Pain Research and Management,

Villemure C et al. – Because both the mediodorsal thalamus and anterior cingulate are involved in pain affect perception, and activation within the prefrontal areas and periaqueductal grey matter were previously shown to correlate with mood–related pain modulation, it is concluded that the ventral striatum is likely implicated in the analgesic effect of positive mood changes induced by pleasant odours on pain unpleasantness.

Methods
  • Functional magnetic resonance imaging studies were conducted in healthy individuals receiving painful heat stimuli in the presence of pleasant or unpleasant odours, which were used to induce positive and negative mood states.
  • Ventral striatum activity was examined in the two mood states.

Results
  • For most subjects, pleasant odours improved mood and reduced pain unpleasantness perception relative to unpleasant odours.
  • In the pleasant odour condition, the maximum activation of both the left and right ventral striatum was positively correlated with the amount of pain reduction.
  • Furthermore, the left and right ventral striatum activations positively covaried with one another, and the right ventral striatum activation positively correlated with that in the periaqueductal grey matter.
  • Both ventral striatum activations negatively covaried with the activation of the right mediodorsal thalamus, left dorsal anterior cingulate cortex, left medial prefrontal cortex and right ventrolateral prefrontal cortex.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Anesthesiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Anesthesiology Articles

1 Should we induce general anesthesia in the prone position? Current Opinion in Anesthesiology, November 19, 2014    Review Article

2 Cranial nerve injuries with supraglottic airway devices: A systematic review of published case reports and series Anaesthesia, November 12, 2014    Evidence Based Medicine

3 The effect of ketamine on hypoventilation during deep sedation with midazolam and propofol: A randomised, double-blind, placebo-controlled trial European Journal of Anaesthesiology, November 14, 2014    Clinical Article

4 The effect of ketamine on hypoventilation during deep sedation with midazolam and propofol: A randomised, double-blind, placebo-controlled trial European Journal of Anaesthesiology, November 3, 2014    Clinical Article

5 Interscalene brachial plexus blocks under general anesthesia in children: Is this safe practice?: A report from the Pediatric Regional Anesthesia Network (PRAN) Regional Anesthesia and Pain Medicine, November 13, 2014    Clinical Article

6 Forearm bier block: a new regional anesthetic technique for upper extremity surgery Annals of Plastic Surgery, August 8, 2014    Review Article

7 The 'Can't Intubate Can't Oxygenate' scenario in pediatric anesthesia: A comparison of the Melker cricothyroidotomy kit with a scalpel bougie technique Paediatric Anaesthesia, November 21, 2014    Clinical Article

8 The potential benefits of the use of regional anesthesia in cancer patients International Journal of Cancer, November 18, 2014    Clinical Article

9 The effects of goal directed fluid therapy based on dynamic parameters on post-surgical outcome: A meta-analysis of randomized controlled trials Critical Care, November 5, 2014    Evidence Based Medicine    Clinical Article

10 The effects of nicardipine or esmolol on the onset time of rocuronium and intubation conditions during rapid sequence induction: A randomized double-blind trial Journal of Anesthesia, November 10, 2014    Clinical Article

11 Protamine requirements in cardiac surgery: Effect of changes in the heparin reference standard Journal of Cardiothoracic and Vascular Anesthesia, November 11, 2014    Clinical Article

12 Techniques for the insertion of the ProSeal laryngeal mask airway: Comparison of the Foley Airway Stylet Tool with the introducer tool in a prospective, randomized study Full Text BMC Anesthesiology, November 24, 2014    Free full text    Clinical Article

13 Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock Journal of Critical Care, November 17, 2014    Clinical Article
Exclusive Author Commentary

14 Early versus delayed administration of norepinephrine in patients with septic shock Critical Care, October 7, 2014    Clinical Article

15 Short-acting spinal anesthesia in the ambulatory setting Current Opinion in Anesthesiology, November 13, 2014    Review Article

16 Effect of intravenous lidocaine on postoperative recovery of patients undergoing mastectomy: A double-blind, placebo-controlled randomized trial Regional Anesthesia and Pain Medicine, November 13, 2014    Clinical Article

17 Meta-analysis of high- versus low-chloride content in perioperative and critical care fluid resuscitation British Journal of Surgery, November 4, 2014    Evidence Based Medicine    Review Article

18 Does topical Amethocaine cream increase first-time successful cannulation in children compared with a eutectic mixture of local anaesthetics (EMLA) cream? A systematic review and meta-analysis of randomised controlled trials Emergency Medicine Journal, November 25, 2014    Clinical Article

19 Management of neuromuscular blockade in ambulatory patients Current Opinion in Anesthesiology, November 21, 2014    Review Article

20 Comparison of subarachnoid block with bupivacaine and bupivacaine with fentanyl on entropy and sedation: A prospective randomized double-blind study Full Text Journal of Anaesthesiology Clinical Pharmacology, October 16, 2014    Free full text    Clinical Article

Indexed Journals in Anesthesiology: Anaesthesia, Anesthesia & Analgesia, Current Anaesthesia and Critical Caremore