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The Diverse Effects of Vasopressors on the Fetoplacental Circulation of the Dual Perfused Human Placenta
Anesthesia & Analgesia, 03/05/2010
Minzter BH et al. – In the dual perfused, single isolated cotyledon, human placental model, exposure of the maternal circulation to ephedrine and phenylephrine caused an increase in FAP, whereas exposure to norepinephrine, epinephrine, and methoxamine did not. The pharmacodynamic mechanisms underlying these differences have yet to be explained. Thus, the clinical implications of the findings are as yet unclear.
