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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Comparison of acoustic and impedance methods with mask capnometry to assess respiration rate in obese patients recovering from general anaesthesia Anaesthesia, July 22, 2014    Clinical Article

2 Monitoring hypnotic effect and nociception with two EEG-derived indices, qCON and qNOX, during general anaesthesia Acta Anaesthesiologica Scandinavica, July 22, 2014    Clinical Article

3 Influence of α-stat and pH-stat blood gas management strategies on cerebral blood flow and oxygenation in patients treated with therapeutic hypothermia after out-of-hospital cardiac arrest: A crossover study Critical Care Medicine, July 22, 2014    Clinical Article

4 Continuous flow using an entrainer and t-piece vs drawover apparatus for inhalational induction of anesthesia in children Paediatric Anaesthesia, July 22, 2014    Clinical Article

5 Effect of corticosteroids on arginine vasopressin after pediatric cardiac surgery Journal of Critical Care, July 22, 2014    Review Article

6 Cardiac dysrhythmias in pediatric patients during general anesthesia Journal of Clinical Anesthesia, July 22, 2014    Clinical Article

7 Initial lactate and lactate change in post–cardiac arrest: A multicenter validation study Critical Care Medicine, July 22, 2014    Clinical Article

8 Plasma angiopoietin 2 concentrations are related to impaired lung function and organ failure in a clinical cohort receiving high-dose interleukin 2 therapy Shock, July 22, 2014    Clinical Article

9 Flurbiprofen and hypertension but not hydroxyethyl starch are associated with post-craniotomy intracranial haematoma requiring surgery British Journal of Anesthesia, July 22, 2014    Clinical Article

10 Modified Blalock Taussig shunt: Comparison between neonates, infants and older children Full Text Annals of Cardiac Anaesthesia, July 22, 2014    Review Article

11 Obesity and 1-year outcomes in older Americans with severe sepsis Critical Care Medicine, July 22, 2014    Clinical Article

12 Identifying critically ill patients at risk for inappropriate antibiotic therapy: A pilot study of a point-of-care decision support alert Critical Care Medicine, July 22, 2014    Clinical Article

13 Tidal ventilation distribution during pressure-controlled ventilation and pressure support ventilation in post-cardiac surgery patients Acta Anaesthesiologica Scandinavica, July 22, 2014    Clinical Article

14 Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: A quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide British Journal of Anesthesia, July 22, 2014    Clinical Article

15 Direct molecular detection of pathogens in blood as specific rule-in diagnostic biomarker in patients with presumed sepsis: our experience on a heterogeneous cohort of patients with signs of infective systemic inflammatory response syndrome Shock, July 22, 2014    Clinical Article

16 Early intensive care unit-acquired hypernatremia in severe sepsis patients receiving 0.9% saline fluid resuscitation Acta Anaesthesiologica Scandinavica, July 22, 2014    Review Article

17 Poor multi-rater reliability in TCM pattern diagnoses and variation in the use of symptoms to obtain a diagnosis Acupuncture in Medicine, July 22, 2014    Clinical Article

18 Effectiveness of blinding: Sham suprapubic incisions in a randomized trial of retropubic midurethral sling in women undergoing vaginal prolapse surgery American Journal of Obstetrics and Gynecology, July 22, 2014    Clinical Article

19 Comprehensive maternal hemorrhage protocols reduce utilization of blood products and improve patient safety American Journal of Obstetrics and Gynecology, July 22, 2014    Clinical Article

20 Pulse pressure variation is not a valid predictor of fluid responsiveness in patients with elevated left ventricular filling pressure Journal of Critical Care, July 22, 2014    Clinical Article

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Highlights in Anesthesiology

Dopamine is associated with increased mortality in septic shock

Based on a meta-analysis of 11 trials involving 2,768 patients with septic shock, treatment with dopamine was associated with a greater risk of 28-day mortality (RR=1.12-1.23) and arrhythmias (RR=2.34) than norepinephrine.

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RBC transfusion decreased mortality in sepsis

As published in Critical Care Medicine, RBC transfusion decreases the risk of mortality in patients with sepsis and septic shock. The study involved 1054 patients in 22 ICUs and SICUs at 12 teaching hospitals in Korea. Of the 1054 patients, 407 received RBC transfusions; the mean pre-transfusion hemoglobin level was 7.7 g/dL. The transfused patients had a lower risk of 7-day (HR = 0.42), 28-day (HR = 0.43), and in-hospital mortality rates (HR = 0.51) than non-transfused patients.

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Statin use decreases pneumonia-associated mortality

As published in Critical Care, current statin use was associated with a decreased hospitalization rate and a decreased 30-day mortality rate in patients with pneumonia. The study group consisted of 70,953 patients with pneumonia who were hospitalized for the first time with 10 age- and gender-matched control patients for each pneumonia patient. The OR for pneumonia was 0.80 amongst current statin users compared to non-users; previous statin use had no effect on the risk of pneumonia. The 30-day mortality rates in patients who were statin users and non-users were 11.3% and 15.1%, respectively (HR=0.73).

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