Comparison of dexmedetomidine and remifentanil for attenuation of hemodynamic responses to laryngoscopy and tracheal intubation Full Text
Korean Journal of Anesthesiology, 08/20/2012
Lee JH et al. – In healthy normotensive patients, the use of dexmedetomidine during anesthetic induction suppressed a decrease in blood pressure due to anesthetic induction and blunted the hemodynamic responses to endotracheal intubation.Methods
- A total of 90 ASA class 1 or 2 patients were randomly assigned to one of 3 groups to receive one of the following treatments in a double-blind manner: normal saline (Group C, n=30), dexmedetomidine 1µg/kg (Group D, n=30), remifentanil 1µg/kg (Group R, n=30).
- Anesthesia was induced with propofol 2mg/kg and rocuronium 0.6mg/kg and maintained with 2 vol% sevoflurane and 50% nitrous oxide in oxygen.
- In group D, dexmedetomidine 1µg/kg was infused for 10min before tracheal intubation.
- Patients in group R was received 1µg/kg of remifentanil 1minute before tracheal intubation.
- The systolic blood pressure, diastolic blood pressure and heart rate were recorded from entrance to operation room to 5min after tracheal intubation.
- The percent increase in systolic and diastolic blood pressure due to tracheal intubation in group D and R were significantly lower than that of group C (P<0.05).
- The heart rate 1min after tracheal intubation was lower in groups R and D than in the group C (P<0.05).