Relationship between 17-hydroxyprogesterone caproate concentrations and gestational age at delivery in twin gestation
American Journal of Obstetrics and Gynecology, 08/09/2012
Caritis SN et al. – 17–hydroxyprogesterone caproate (17–OHPC) may adversely impact gestational age at delivery in women with twin gestation.Methods
- Blood was obtained between 24–28 weeks (epoch 1) and 32–35 weeks (epoch 2) in 217 women with twin gestation receiving 17–OHPC or placebo.
- Gestational age at delivery and concentrations of 17–OHPC, 17–hydroxyprogesterone, progesterone, C–reactive protein (CRP) and corticotrophin releasing hormone were assessed.
- Women with higher concentrations of 17–OHPC delivered at earlier gestational ages than women with lower concentrations (p<0.001).
- Women receiving 17–OHPC demonstrated significantly higher (p=0.005) concentrations of CRP in epoch 1 than women receiving placebo but CRP values were similar in epoch 2 in both groups.
- A highly significant (p<0.0001) positive relationship was observed between 17–OHPC concentration and progesterone and 17–hydroxyprogesterone concentrations at both epochs.
- CRH concentrations did not differ by treatment group.