Aries MJH et al. – Real–time optimal cerebral perfusion pressure (CPPopt) could be identified during the recording time of majority of the patients. Patients with a median CPP close to CPPopt were more likely to have a favorable outcome than those in whom median CPP was widely different from CPPopt. Deviations from individualized CPPopt were more predictive of outcome than deviations from a common target CPP. CPP management to optimize cerebrovascular pressure reactivity should be the subject of future clinical trial in severe traumatic head–injury patients.Methods
- A total of 327 traumatic head-injury patients admitted between 2003 and 2009 with continuous monitoring of arterial blood pressure and intracranial pressure.
- Arterial blood pressure, intracranial pressure, and CPP were continuously recorded, and pressure reactivity index was calculated online.
- Outcome was assessed at 6 months.
- An automated curve fitting method was applied to determine CPP at the minimum value for pressure reactivity index (CPPopt).
- A time trend of CPPopt was created using a moving 4-hr window, updated every minute.
- Identification of CPPopt was, on average, feasible during 55% of the whole recording period.
- Patient outcome correlated with the continuously updated difference between median CPP and CPPopt (chi-square=45, p<.001; outcome dichotomized into fatal and nonfatal).
- Mortality was associated with relative “hypoperfusion” (CPP<CPPopt), severe disability with “hyperperfusion” (CPP>CPPopt), and favorable outcome was associated with smaller deviations of CPP from the individualized CPPopt.
- While deviations from global target CPP values of 60mmHg and 70mmHg were also related to outcome, these relationships were less robust.