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See Latest ArticlesIncrease in Quality, but Not Quantity, of Clinical Trials in Acute Pain: 1992 Versus 2007
Anesthesia & Analgesia, 10/21/09
Reeves MD – The annual number of published clinical trials in acute postoperative pain in adults has changed little in 15 yr and, as a fraction of all clinical trials published in the six highest impact journals in anesthesiology, has actually decreased from 16% (95% confidence interval: 12–20) to 11% (95% confidence interval: 9–15). However, the methodological quality of reports has improved, with explicit statements on power analysis, allocation concealment, and specification of primary end points exceeding 90% of reports in 2007. There has been a shift in hypothesis interests away from neuraxial analgesia and toward multimodal analgesia.
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