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See Latest ArticlesSynthesis and pharmacological properties of a new fluorescent opioid peptide analog
Pharmacological Reports, 10/12/09
Lukowiak M et al. – This paper reports the pharmacological properties of a new analog in which one pharmacophore of biphalin was replaced with fluorescent 7–succinylamido–4–methyl–coumarin. The resulting compound displays an affinity for mu opioid receptors that is a delta opioid receptor comparable to biphalin but with an affinity that is over a hundred times lower. This mu opioid selective fluorescent peptide analog could be applied in pharmacokinetic and pharmacodynamic studies of biphalin related analogs.
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