Anesthesia

Your Article Summary

Efficacy and safety of lornoxicam compared with placebo and diclofenac in acute sciatica/lumbo-sciatica: an analysis from a randomised, double-blind, multicentre, parallel-group study
International Journal of Clinical Practice, 10/12/09

Herrmann WA et al. – These data indicate that the analgesic efficacy of lornoxicam (LNX) is superior to placebo and similar to diclofenac in acute sciatica/lumbo–sciatica.

Methods

• Male or female patients (n = 171) aged 18–70 years with acute sciatica or lumbo–sciatica.
• The dosage of study treatment was 8–24 mg/day LNX, 100–150 mg/day diclofenac or placebo.

Results

• In total, 164 patients completed the study.
• Significant differences in PID between LNX and placebo were seen in the time interval 3–8 h after the first dose including pain intensity difference from baseline to 6 h (PID0–6 h).
• Secondary end–points favoured LNX vs. placebo, but in general were not significantly different.
• LNX and diclofenac had similar analgesic effect. Incidence and severity of adverse events were comparable for the three treatments; overall tolerability was rated as very good/good by 93% of the patients.