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Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen
Cochrane Reviews, 10/09/09
Chin J et al. – Tamoxifen is commonly used by women to reduce the risk of breast cancer recurrence. Tamoxifen can also cause abnormal changes to the lining of the womb (endometrium), including polyps and cancer...The Mirena LNG–IUS appears to prevent the development of benign endometrial polyps in breast cancer patients taking tamoxifen, over a one–year period. There is no clear evidence from the available randomised controlled trials that LNG–IUS prevents endometrial hyperplasia or adenocarcinoma in these patients. Larger studies are necessary to assess the effects of LNG–IUS in preventing endometrial hyperplasia and endometrial cancer, and to determine whether LNG–IUS might have an impact on the risk of breast cancer recurrence.
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