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See Latest ArticlesPreclinical and Early Clinical Investigations Related to Monoaminergic Pain Modulation
Neurotherapeutics, 10/05/09
Bannister et al. – The links between pain and the comorbidities of sleep problems, anxiety, and depression may be due to the dual roles of noradrenaline and of 5–HT in these functions and also in pain. These controls appear, in the cases of peripheral neuropathy, spinal injury, and cancer–induced bone pain to be driven by altered peripheral and spinal neuronal processes; in opioid–induced hyperalgesia, however, the same changes occur without any pathophysiological peripheral process. Thus, in generalized pain states in which fatigue, mood changes, and diffuse pain occur, such as fibromyalgia and irritable bowel syndrome, one could suggest an abnormal engagement of descending facilitations with or without reduced inhibitions but with central origins. This would be an endogenous central malfunction of top–down processing, with the altered monoamine systems underlying the observed symptoms. A number of analgesic drugs can either interact with or have their actions modulated by these descending systems, reinforcing their importance in the establishment of pain but also in its control.
Today in Basic Science/Genetics...keeping you current
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Advances in fibromyalgia treatment: understanding endogenous pain modulation
International Journal of Clinical Rheumatology, 11/09/09
How triggers trigger acute migraine attacks: A hypothesis
Medical Hypotheses, 11/23/09
Functional activation of proline-rich tyrosine kinase2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
BMC Musculoskeletal Disorders, 11/18/09
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Advances in fibromyalgia treatment: understanding endogenous pain modulation
International Journal of Clinical Rheumatology, 11/09/09
Insights into the pathogenesis of axial spondyloarthropathy based on gene expression profiles
Arthritis Research & Therapy, 11/13/09
How triggers trigger acute migraine attacks: A hypothesis
Medical Hypotheses, 11/23/09
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Transient Ischemic Attack after Tissue Plasminogen Activator: Aborted Stroke or Unnecessary Stroke Therapy
Cerebrovascular Diseases, 11/10/09
Neonatal seizures and Long QT Syndrome: A cardiocerebral channelopathy
Epilepsia, 11/10/09
Neurological symptoms in patients with biopsy proven celiac disease
Movement Disorders, 11/03/09
Today in Family Medicine...keeping you current
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Osteoarthritis: A review of treatment options
Geriatrics, 10/21/09
Escitalopram and Venlafaxine for the Prophylaxis of Migraine Headache Without Mood Disorders
Clinical Neuropharmacology, 10/02/09
Use of oral ketamine in chronic pain management: A review
European Journal of Pain, 11/02/09
Today in Internal Medicine...keeping you current
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Osteoarthritis: A review of treatment options
Geriatrics, 10/21/09
Escitalopram and Venlafaxine for the Prophylaxis of Migraine Headache Without Mood Disorders
Clinical Neuropharmacology, 10/02/09
Use of oral ketamine in chronic pain management: A review
European Journal of Pain, 11/02/09
Today in Neurology...keeping you current
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Antithrombotic medication for stroke prevention
Expert Review of Cardiovascular Therapy , 10/20/09
Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents
JAMA, 10/28/09
Escitalopram and Venlafaxine for the Prophylaxis of Migraine Headache Without Mood Disorders
Clinical Neuropharmacology, 10/02/09
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Escitalopram and Venlafaxine for the Prophylaxis of Migraine Headache Without Mood Disorders
Clinical Neuropharmacology, 10/02/09
Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial
Diabetic Medicine, 10/01/09
Cluster Headache
Pain Practice, 10/30/09
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Impulsivity, personality and bipolar disorder
European Psychiatry , 11/06/09
The role of dopamine in bipolar disorder
Bipolar Disorders, 11/18/09
Serum brain-derived neurotrophic factor in bipolar and unipolar depression: A potential adjunctive tool for differential diagnosis
Journal of Psychiatric Research, 11/20/09
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Impulsivity, personality and bipolar disorder
European Psychiatry , 11/06/09
Olive Oil and Cognition: Results from the Three-City Study
Dementia and Geriatric Cognitive Disorders, 11/02/09
Serum brain-derived neurotrophic factor in bipolar and unipolar depression: A potential adjunctive tool for differential diagnosis
Journal of Psychiatric Research, 11/20/09
Today in Pain Management...keeping you current
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Effect of Depression Treatment on Chronic Pain Outcomes
Psychosomatic Medicine, 10/30/09
Stress as a Key Concept in Chronic Widespread Pain and Fatigue Disorders
Journal of Musculoskeletal Pain , 11/16/09
Prevalence of Depression Symptoms in Outpatients with a Complaint of Headache
Journal of the American Board of Family Medicine, 11/09/09
Today in Pain Management...keeping you current
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Osteoarthritis: A review of treatment options
Geriatrics, 10/21/09
Use of oral ketamine in chronic pain management: A review
European Journal of Pain, 11/02/09
Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial
Diabetic Medicine, 10/01/09
Today in Pain Management...keeping you current
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Osteoarthritis: A review of treatment options
Geriatrics, 10/21/09
Use of oral ketamine in chronic pain management: A review
European Journal of Pain, 11/02/09
Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial
Diabetic Medicine, 10/01/09
Today in Pain Medicine...keeping you current
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Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial
Diabetic Medicine, 10/01/09
Acute back pain: benefits and risks of current treatments
Current Medical Research and Opinion, 11/20/09
Paraplegia Following Image-Guided Transforaminal Lumbar Spine Epidural Steroid Injection: Two Case Reports
Pain Medicine, 10/29/09
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Effect of Depression Treatment on Chronic Pain Outcomes
Psychosomatic Medicine, 10/30/09
The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: A cross-sectional study
Arthritis Research & Therapy, 11/03/09
The Effects of Sucrose Consumption on Left-Frontal Asymmetry and Anger in Persons with Fibromyalgia Syndrome
Journal of Musculoskeletal Pain , 11/16/09
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An algorithm for the pharmacological treatment of depression
Acta Psychiatrica Scandinavica, 11/04/09
Is Monotherapy as Good as Polypharmacy in Long-Term Treatment of Bipolar Disorder
Canadian Journal of Psychiatry, 11/16/09
Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents
JAMA, 10/28/09
Today in Psychiatry...keeping you current
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An algorithm for the pharmacological treatment of depression
Acta Psychiatrica Scandinavica, 11/04/09
Is Monotherapy as Good as Polypharmacy in Long-Term Treatment of Bipolar Disorder
Canadian Journal of Psychiatry, 11/16/09
Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents
JAMA, 10/28/09
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