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Stressful events can damage neonatal brain through a complexity of events including free radical (FR) generation. The authors examined whether pain provoked by a routine heel prick can generate an increase in potentially harmful FR in neonatal blood...A significant correlation was also found between advanced oxidation protein products (AOPP) blood levels ratio (sample B/sample A) in each baby, and the correspondent level of pain. These data show that even common routine procedures can be potentially harmful for the newborn if they provoke a high level of pain.

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