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See Latest ArticlesMethylnaltrexon. A new approach for therapy of opioid-induced constipation
Schmerz, 09/18/09
Chappell D et al. – Conventional therapy can be insufficient in providing satisfactory relief of constipation, mostly because this opioid–induced bowel hypomotility can be laxative–resistant. Moreover, constipation does not decrease during the course of therapy as do other side effects. It is well known that opioid–induced constipation is mediated via activation of µ–opioid receptors in the gastrointestinal tract. Selective peripheral mu–receptor antagonists (such as methylnaltrexone, Relistor) can effectively treat opioid–induced constipation. An interference with central analgesia does not occur as the molecules cannot pass the blood–brain barrier due to their charged states. A reduction of opioid therapy or the development of withdrawal symptoms can be avoided. Studies have shown that methylnaltrexone is not only safe and efficient for chronically constipated palliative care patients but offers promising therapeutic options for further patient collectives.
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